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NEW YORK, June 28, 2007 – Researchers from Columbia University Medical Center received a $2.5 million grant from the National Institute of Biomedical Imaging and Bioengineering to use stem cells to engineer soft tissue, developing a process that should ultimately allow scientists to use a patient’s own stem cells to develop tissue for facial reconstruction following disfiguring injuries from war, cancer surgery or accidents.
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Jeremy Mao, D.D.S, Ph.D. |
The Columbia research team, led by Jeremy Mao, D.D.S., Ph.D., associate professor of dental medicine, aims to create long-lasting soft tissue implants from mesenchymal stem cells harvested from the patient’s own bone marrow or adipose tissue. Mesenchymal stem cells can differentiate into bone, fat, cartilage and other types of cells.
“Our research has shown that mesenchymal stem cells can create tissue that is biocompatible with the host and that the continuous generation of these cells can replenished the implant to reduce shrinkage,” said Dr. Mao.
Currently, surgeons often graft from the
patient’s own tissue, which creates additional wounds. Grafted cells
also fail to stay alive, causing implants to shrink up to 70 percent
and lose their shape and volume. Attempts have also been made to use
fat cells left over after liposuction, but those cells also have a
limited lifespan.
The Columbia team of
biologists, biomedical engineers, biomaterial scientists, imaging
experts and surgeons has shown that human mesenchymal stem cells can
create long-lasting implants in mice. The implant is created by placing
the stem cells into an FDA-approved scaffold that mimics the conditions
needed to turn stem cells into fat cells. Because stem cells have the
ability to replicate and differentiate, they can regenerate the soft
tissue, keeping the implant from shrinking. In mice, these cells have
successfully created fat cells that could be implanted and retained
their size and shape for at least a month.
Because the implants can be molded into any size or shape, they could also be used for breast reconstruction.