Daniel S. Oh, PhD

Profile Headshot

Overview

Academic Appointments

  • Assistant Professor of Materials Sciences (in Dental Medicine)

Languages

  • Korean

Credentials & Experience

Education & Training

  • BS, 1990 Material Engineering , Yonsei University
  • MS, 1995 Material Engineering, Yonsei University
  • PhD, 2003 Biomaterial, Yonsei University

Honors & Awards

  • 2016 General Session Organizer, International Association for Dental Research (IADR), “Microenvironments for Mineralized Tissue Engineering”.
  • 2013 Keynote Speaker; Korean Society for Biomaterials
  • 2013 Keynote Address, IADR/AADR General Session; Scaffold and Bone Regeneration
  • 2012 Session Organizer, Society for Biomaterials (SFB), “Microenvironments for osteogenesis and vasculogenesis - physical, chemical, and biological perspectives”.
  • 2011 Best Scientific Poster Presentation, Academy of Osseointegration (AO)
  • 2010 Best Scientific Poster Presentation, Academy of Osseointegration (AO)
  • 2007 Unilever Hatton Award, American Association for Dental Research (AADR) 
  • 2005 Research Award, Tennessee Biomedical Engineering Conference

Research

Welcome to Dr. Daniel S. Oh’s Lab at College of Dental Medicine

The research interest of our laboratory is the development of bio-functional materials for implantology, regenerative/restorative medicine by means of tissue engineering, delivery systems, and nanotechnology. In particular, we are interested in developing bio-inspired micro-environmental platform technologies to engineer tissues and organs as well as skeletal organoid to study mechanisms of bone metastases. We aim to further the understanding of microenvironments of stem cells in both hard and soft tissues using our invention technology (US patent application publication: US 2011/0313538 A1). Our research lies at the interfaces of fundamental material science, biology and clinical applications at the macro-, micro- and nano- scale levels. Our basic understanding of biology inspires the development of bio-functional materials for medical applications. Our hope is to use these systems to help bone regeneration and integration, so that entire bone defects can be restored to their original states. We believe quality work depends on idea, passion and persistence. The students and postdoc fellows who join our group will have opportunities to learn from and work with engineers, biologists and clinicians.

Research Program

Our research interests are in the areas of bio-functional materials, implant devices, drug delivery, musculoskeletal tissue engineering, microenvironments for bone development and 3D culture technology. Our research methodology includes concept design and development, characterization and evaluation of design, both in vitro and in vivo validation of novel bio-functional materials and implant devices. Our current program focuses on the following themes: Enabling technologies for 3D shaped bone reconstruction, surface nanotechnology for osseointegrated implant devices, and creating microenvironments for osteogenesis and angio-/vasculogenesis.

1.Enabling technology for 3D shaped bone reconstruction and restoration

2.Microenvironment for osteogenesis and angio-/vasculogenesis

3.Surface nanotechnology to improve osseointegration in implant devices

4.3D cancer model to study cancer progression and test for chemotherapeutic agents.

Grants

ERK SIGNALING IN INFLAMMATORY BONE LOSS (Federal Gov)

Jun 1 2008 - Jan 31 2018

ENHANCEMENT OF BONE AUGMENTATION AND PREVENTION OF INFETCION FOR DENTAL IMPLANT (Private)

Jan 1 2016 - Dec 31 2016

MECHANOBIOLOGICAL MECHANISM FOR INFLAMMAORY BONE LOSS (Federal Gov)

Apr 4 2007 - Apr 30 2016

Selected Publications

  • Daniel S. Oh, Alia Koch, Sidney B. Eisig, Sahng-Gyoon Kim, Yoonhyuk Kim, Jae-Hyuck Shim. Distinctive capillary action by micro-channels in bone-like templates can enhance recruitment of cells for restoration of large bony defect. J Vis Exp. 2015 Sep 11;(103). doi: 10.3791/52947.
  • Min-Ho Hong, Yoon Hyuk Kim, Danaa Ganbat, Jung-Ho Back, Chunsik Bae, Daniel S. Oh. Capillary action: enrichment of retention and habitation of cells via micro-channeled scaffolds for massive bone defect regeneration. J Mater Sci Mater Med. 2014;25(8):1991-2001.
  • Rathbone CR, Guda T, Singleton BM, Oh DS, Appleford MR, Ong JL, Wenke JC. Effect of cell-seeded hydroxyapatite scaffolds on rabbit radius bone regeneration. J Biomed Mater Res A. 2014;102(5):1458-66.
  • Daniel S. Oh, Young-Joon Kim, Min-Ho Hong, Myung-Ho Han, Kyung-Soo Kim. Effect of capillary action on bone regeneration in micro-channeled ceramic scaffolds. Ceramics International. 2014;40(8):9583-9.
  • Guda T, Walker JA, Singleton B, Hernandez J, Oh DS, Appleford MR, Ong JL, Wenke JC. Hydroxyapatite scaffold pore architecture effects in large bone defects in vivo. J Biomater Appl. 2014;28(7):1016-27.
  • Min-Ho Hong, Sung-Min Kim, Myung-Ho Han, Yoon Hyuk Kim,Yong-Keun Lee, Daniel. S. Oh. Evaluation of microstructure effect of the porous spherical β-tricalcium phosphate granules on cellular responses. Ceramics International. 2013;40(4):6095-102.
  • Daniel S. Oh, Yoon Hyuk Kim, Danaa Ganbat, Myung-Ho Han, Phillip Lim, Jung-Ho Back, Francis Y. Lee, Hesham Tawfeek. Bone marrow absorption and retention properties of engineered scaffolds with micro-channels and nano-pores for tissue engineering: a proof of concept. Ceramics International. 2013;39(7):8401-10.
  • John O. Grippo, Daniel S. Oh. A Classification of the Mechanisms Production Pathological Changes. J Med Eng Technol. 2013;37(4):259-63.
  • Jun Sik Son, Mark Appleford, Joo L. Ong, Joseph C. Wenke, Jong Min Kim, Seok Hwa Choi, Daniel S. Oh. Porous hydroxyapatite scaffold with three-dimensional localized drug delivery system using biodegradable microspheres. Journal of Controlled Release. 2011;153(2):133-40.