Clinical Trials
The College of Dental Medicine is improving oral health through innovative, multidisciplinary research that involves developing and testing ground-breaking treatment strategies for patients dental issues. Clinical trials help us translate our research into patient care.
List of clinical trials actively recruiting patients
Volumetric Changes Associated with Immediate Implant Placement and Bio-Oss Collagen: A Randomized Controlled Clinical Trial
The purpose of the study is to evaluate the soft and hard tissue dimensional changes in the esthetic zone after extraction of teeth in combination with placement of a dental implant that is immediately loaded with a provisional restoration. In addition, the impact of placing a graft material (Bio-Oss Collagen®, Geistlich Pharma AG) into the gap between the implant and the labial plate of bone will be evaluated. 32 subjects will have an immediate dental implant placed in the maxillary anterior region (#4-12) after extraction of a hopeless tooth. 16 subjects will be randomly selected to receive Bio-Oss Collagen ® (Test group) and 16 subjects will have no graft (Control group) in the gap between the implant and the labial plate of bone. Patients will be followed for one year and dimensional changes will be recorded.
Sponsor: Geistlich Pharma AG
Study recruitment: closed
Stage of Study: follow-up period
Bone-Implant Contact after Maxillary Sinus Augmentation with Two Different Biomaterials
Study Design: This study is designed as a randomized, controlled split-mouth study in patients who require bilateral sinus augmentation. It aims to characterize bone formation and remodeling after maxillary sinus augmentation and simultaneous implant placement.
This is a randomized, controlled split-mouth study to compare bone formation around microimplants (SuperLine, Dentium) with a sandblasted, large grit, acid etched (SLA) surface placed at the time of maxillary sinus floor augmentation with a synthetic material (Hydroxylapatite scaffolds coated with ß-tricalcium phosphate, Osteon TM, Dentium) and deproteinized bovine bone (Bio-Oss®, Osteohealth). We will include patients who require bilateral sinus augmentation (n=15) and graft one side with synthetic material and the other with bovine bone. Microimplants will be placed vertically from the alveolar crest at the time of sinus augmentation, penetrating residual bone and the grafting material. After 6-8 months of healing, microimplants will be retrieved together with surrounding bone for histological analysis and dental implants placed simultaneously. Implants will be restored 2-3 months later.
Sponsor: Dentium, USA
Study recruitment: closed
Stage of Study: follow-up period
In Vivo Assessment of Optical Efficacy of Pink Neck Implant And Pink Abutment on Soft Tissue Esthetics
Esthetic results with dental implants are usually predictable, however cases where the gums and the bone are too thin, can present an esthetic challenge. In these cases, the metallic dental implant can show through the thin gums, producing a grayish unesthetic look to the gums around the implant crown. This study evaluates the use of a pink colored neck implant and pink post named Genesis by Keystone Dental. Healthy patients that have an unrestorable upper front tooth will be randomized to receive either a pink implant or a conventional implant to replace the broken tooth. Color measurements of the gums around the implant, will be compared between pink and conventional gray implants.
Sponsor: Keystone Dental, Inc.
Study recruitment: closed
Stage of study: follow-up period
An Open, Prospective, Randomized, Multicenter Study Comparing Osseospeed™ Plus With Osseospeed™ Tx In Partially Edentulous Maxillae And Mandibles: A 5-Year Follow-Up Study
This study is being carried out to evaluate the long term healing of the bone around two dental implants (OsseoSpeedTM Plus and OsseoSpeedTM TX). Both implants are manufactured by Dentsply implants. The OsseoSpeedTM Plus implant is a further development of the OsseoSpeed TX implant, the modifications are designed to give more stability to the new implant. Approximately 120 subjects will take part at six different dental clinics in Europe, Canada and the USA. Participants will be divided randomly into two groups, half will receive OsseoSpeed Plus and the other half will receive OsseoSpeed TX dental implants. All subjects will be followed for up to five years, in order to measure the bone level around the implant and the survival of the implants as well.
Sponsor: Astra Tech (Please note: Astra Tech was acquired by Dentsply in 2011).
Study recruitment: closed
Stage of study: follow-up period
A Retrospective Multicenter Study Evaluating ATLANTIS™ Abutments on Implants from Four Manufacturers
Dental implants are restored with an abutment (post) that holds a crown. ATLANTIS abutments are made to fit different implant companies. These abutments are tested to make sure they present clinical properties to endure the oral environment. This study is being done to evaluate the long-term performance of ATLANTIS abutments used with different implants, after being in function in patient’s mouths for one year or more. Approximately 120 subjects will take part at six different dental clinics in USA.
Study recruitment: closed
Stage of study: follow-up period