Chang Hun Lee, PhD

Profile Headshot

Overview

Academic Appointments

  • Assistant Professor of Craniofacial Engineering (in Dental Medicine)

Dr. Lee received his BS in Biomedical Engineering from Inje University (South Korea) in 2002. He completed his Ph.D. in Biomedical Engineering from Columbia University in 2010 and received postdoctoral training until 2014 at Center for Craniofacial Regeneration in College of Dental Medicine. Dr. Lee is currently an Assistant Professor of Craniofacial Engineering (in Dental Medicine).

Dr. Lee’s research is focused on musculoskeletal and craniofacial tissue regeneration by harnessing endogenous stem/progenitor cells using advanced scaffold systems, control-delivery system, and translational animal models. In his early research career, Dr. Lee developed an innovative strategy for tissue regeneration by homing body’s own stem cells into defect sites. He applied the new strategy for successful regeneration of synovial joint condyle, tendons, and knee meniscus that resulted in publications in prestigious journals, including The Lancet, Science Translational Medicine, and Journal of Clinical Investigation. His recent publication in Journal Clinical Investigation was highlighted in New England Journal of Medicine in 2016. For the last 10 years of his research career including graduate programs, Dr. Lee’s publications have been cited over 2,200 times (as of Sept 2017), showing the high impact of his research in the field.

Dr. Lee is a recipient of New Investigator Recognition Award at Orthopedic Research Society (2013), Best Research Mentor Award from Bergen Academy (2011), Webster Jee Young Investigator Award at International Chinese Hard Tissue Society (2009), Young Investigator Award at Society of Physical Regulation in Biology and Medicine (2008), University Dean Award from Inje University (2004), and International fellowship award from Korea Science and Engineering Foundation (2003). He was an invited speaker at Society for Biomaterials (2014) and Gordon Research Conference on Collagen (2011). He served as an invited moderator and reviewer at the annual meeting of Orthopedic Research Society (2016) and a journal reviewer for Journal of Clinical Investigation, Journal of Orthopedic Research, Tissue Engineering, Biomaterials, and Macromolecular Bioscience, Plos One, Advanced Healthcare Materials, and more. Dr. Lee was a member in NIH BTSS study section (2015), a grant review panel in Maryland Industrial Partnerships Program (MIPS) (2016) and European Research Council (2017).

To date, Dr. Lee has mentored over 30 post-graduate, dental and undergraduate students. Many of his students received research awards, including Birnberg research awards, AADR fellowship award, ASDA best presentation award, Melvin Morris Awards, and Hatton Award finalist.

Languages

  • Korean

Credentials & Experience

Education & Training

  • PhD, 2010 Biomedical engineering, Columbia University, NY

Honors & Awards

Invited Speaker, Albert Einstein Musculoskeletal Repair and Regeneration Symposium (2017)

Invited Speaker, Hospital for Special Surgery Orthopaedic Surgery (2017)

Podium presentation award (1st place), ORS meeting Meniscus Section (2017)

Invited Speaker, Korean Scientist and Engineers Association (2017)

Invited Speaker, NIH Bridge cohort, City University of New York (2016)

Invited Speaker, Society for Biomaterials (2015)

New Investigator Recognition Award (NIRA), Orthopedic Research Society (2013)

AADR Hatton Award Finalist, IADR/AADR (2013)

Invited Speaker, Gordon Research Conference on Collagen (2011)

New Investigator Recognition Award Finalists (42 out of 986), Orthopedic Research Society (2011)

Best Research Mentor Award, Bergen Country Academy (2011)

Webster Jee Young Investigator Award, International Chinese Hard Tissue Society (2009).

Young Investigator Award, Society of Physical Regulation in Biology and Medicine (2008).

University Dean Award, Inje University, Korea (2004).

Fellowship award, Korea Science and Engineering Foundation (2004).

Full tuition scholarships for whole undergraduate study.

Full tuition scholarships for whole graduate study.

Research

Our goal is to regenerate diseased or damaged connective tissues by harnessing endogenous stem/progenitor cells.

Research Interests

  • Orthopedics and musculoskeletal tissue engineering
  • Regeneration of orthopedic and dental tissues by harnessing endogenous stem cells
  • 3D printed scaffolds system as controlled delivery system for complex tissue regeneration

Grants

SEAMLESS HEALING OF AVASCULAR MENISCUS TEARS BY STEM CELL RECRUITMENT (Federal Gov)

Sep 6 2017 - Jun 30 2021

TMJ DISC REGENERATION BY 3D-PRINTED BIOSCAFFOLDS IN A PRE-CLINICAL ANIMAL MODEL (Federal Gov)

Apr 1 2017 - Mar 31 2019

MULTIDISCIPLINARY TRAINING IN TMJ DISORDERS/PAIN: INTEGRATING BASIC, TRANSLATIONAL AND CLINICAL SCIENCE (Federal Gov)

Jul 1 2013 - Jun 30 2018

PRE-CLINICAL MODELS OF ODONTIC ANALOGS BY ENDOGENOUS STEM CELLS (Federal Gov)

Jun 10 2013 - May 31 2018

TMJ DISC REGENERATION BY SPATIOTEMPORAL DELIVERY OF GROWTH FACTORS IN 3D-PRINTED SCAFFOLDS (Private)

Jan 1 2016 - Dec 31 2016

ASSESSMENT OF COLLAGEN I THERAPY IN PERIODONTAL REGENERATION: ACCELERATION OF BONE AND SOFT TISSUE ENGINEERING IN CONJUNCTION WITH DENTAL IMPLANT (Private)

Jun 1 2016 - Nov 30 2016

TRACKING STEM CELLS IN ENGINEERED TISSUE AND ORGANS IN VIVO AND IN REAL TIME (Federal Gov)

Sep 15 2009 - Aug 31 2014

REGENERATION OF CLINICALLY RELEVANT OROFACIAL TISSUES IN PRE-CLINICAL MODELS (Federal Gov)

Sep 25 2009 - Aug 31 2013

FUNCTIONAL SYNOVIAL JOINT REPLACEMENT BY STEM CELL HOMING (NY State Gov)

Jan 1 2009 - Dec 31 2012

Selected Publications

Tarafder S, Chen E, Jun Y, Kao K, Sim KH, Back J, Lee FY, Lee CH, Tendon Stem/Progenitor Cells Regulate Inflammation in Tendon Healing via JNK and STAT3 Signaling, FASEB J, In press.

Shah BS, Chen M, Suzuki T, Lee CH, He L, Xiang L, Ahn JA, Ding S, Mao JJ, Pyrintegrin Induces Soft Tissue Formation by Transplanted or Endogenous Cells, Scientific Reports. 2017, 27;7:36402

Cho H, Tarafder S, Fogge M, Kao K, Lee CH, Periodontal ligament stem/progenitor cells with protein-releasing scaffolds for cementum formation and integration on dentin surface, Connective Tissue Research. 2016, 57(6):488-495

Tarafder S, Koch A, Jun Y, Chu C, Awadallah MR, Lee CH, Micro-Precise Spatiotemporal Delivery System Embedded in 3D Printing for Complex Tissue Regeneration, Biofabrication. 2016; 8(2):025003.

Legemate K, Tarafder S, Jun Y, Lee CH, Engineering Human TMJ Disc with Protein-Releasing 3D Printed Scaffolds, Journal of Dental Medicine. 2016, doi:10.1177/0022034516642404.

Lee CH+, Lee FY, Tarafder S, Kao K, Jun Y, Yang G, Mao JJ, Harnessing Endogenous Stem/Progenitor Cells for Tendon Regeneration, J Clin Invest. 2015, 1;125(7):2690-701. *High IF (14.15) *Highlighted in New England Journal of Medicine *Selected as Top 10 CUMC research in 2015, +First and corresponding author

Vorys GC, Bai H, Chandhanayingyong C, Lee CH, Compton JT, Caldwell JM, Gardner TR, Mao JJ, Lee FY, Optimal internal fixation of anatomically shaped synthetic bone grafts for massive segmental defects of long bones, Clin Biomech. 2015, 30(10):1114-8.

Lee CH, Rodeo SA, Fortier LA, Lu C, Erisken C, Mao JJ, Protein-Releasing Polymeric Scaffolds Induce Fibrochondrocytic Differentiation of Endogenous Cells for Knee Meniscus Regeneration in Sheep, Science Trans Med. 2014, 6(266):266ra171. *High IF (15.845) *Selected as Top 10 CUMC research in 2014

Lee CH, Hajibandeh J, Fan A, Suzuki T, Shang P, Mao JJ, 3D Printed Multiphase Scaffolds for Regeneration of Dental Root-Periodontium Complex, Tissue Engineering Part A. 2014, 20(7-8):1342-51

Jiang N, Zhou J, Chen M, Schiff MD, Lee CH, Kong K, Embree M, Zhou Y, Mao JJ, Postnatal Epithelium and Mesenchyme Stem/Progenitor Cells in Bioengineered Amelogenesis and Dentinogenesis. Biomaterials. 2014, 35(7):2172-80

Amorosa LF, Lee CH, Aydemir AB, Nizami S, Hsu A, Patel NR, Gardner TR, Navalgund A, Kim D-G, Park SH, Mao JJ, Lee FY, Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study, Int. J. Nanomed. 2013, 8:1637-43.

Nie H, Lee CH, Tan J, Lu C, Mendelson A, Chen M, Embree MC, Kong K, Shah B, Wang S, Cho S, Mao JJ, Musculoskeletal Tissue Engineering by Endogenous Stem/Progenitor Cells. Cell and Tissue Res. 2012, 347(3):665-76.

Yildirim S, Fu SY, Kim K, Zhou H, Lee CH, Li A, Kim SG, Wang S, Mao JJ, Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine. Int J Oral Sci. 2011, 3(3):107-16.

Yuan Z, Nie H, Wang S, Lee CH, Li A, Fu SY, Zhou H, Chen L, Mao JJ, Biomaterial selection for tooth regeneration. Tissue Eng Part B Rev. 2011, 17(5):373-88.

Suzuki T*, Lee CH*, Chen M, Zhao W, Fu SY, Qi JJ, Chotkowski G, Eisig SB, Wong A, Mao JJ,  Induced migration of dental pulp stem cells for in vivo pulp regeneration. J Dent Res. 2011, 90(8):1013-8. *Equal contributor

Lee CH, Cook J, Koch P, Moioli EK, Xin X, Mao JJ, Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study, The Lancet, 2010, 376(9739): 440-8. *High IF (45.217) *Featured in Cover *Highlighted by NIH/NIBIB press and media *Cited more than 290 times.

Lee CH, Moioli EK, Shah B, Mao JJ, CTGF directs fibroblast differentiation from human mesenchymal stem/stromal cells and defines connective tissue healing in a rodent injury model. J Clin Invest, 2010, 120(9):3340-9. *High IF (14.15) *Highlighted by NIH/NIDCR press *Cited 158 times.

Kim K+, Lee CH+, Kim R, Mao JJ, Anatomically shaped tooth and periodontal regeneration by cell homing, J Dent Res, 2010, 89(8):842-7. +Equal contribution. *Highlighted by NIH/NIDCR press and media

Yang R, Chen M, Lee CH, Yoon R, Lal S, Mao JJ, Clones of Ectopic Stem Cells in the Regeneration of Muscle Defects in Vivo, Plos ONE, 2010, 5(10):e13547

Kim JY, Xin X, Moioli EK, Chung J, Lee CH, Chen M, Fu SY, Koch PD, Mao JJ, Regeneration of Dental Pulp-Like Tissue by Chemotaxis-induced Cell Homing, Tissue Eng Part A, 2010, 16(10):3023-31.

Lee CH, Marion NW, Hollister SJ, Mao JJ, Tissue Formation and Vascularization of Anatomically Shaped Human Tibial Condyle In Vivo, Tissue Eng Part A, 2009 Dec;15(12):3923-30.

Mao J, Stosich MS, Moioli E, Lee CH, Fu S, Bastian B, Eisig S, Zemnick C, Ascherman J, Wu J, Rohde C, Ahn J. Facial Reconstruction by Biosurgery: Cell Transplantation vs. Cell Homing. Tissue Eng Part B Rev. 2009 Apr;16(2):257-62.

Stosich MS, Moioli EK, Wu JK, Lee CH, Rohde C, Yoursef AM, Ascherman J, Diraddo R, Marion NW, Mao JJ. Bioengineering strategies to generate vascularized soft tissue grafts with sustained shape. Methods. 2009, 47(2):116-21.

Shin HJ, Lee CH, Cho IH, Kim YJ, Lee YJ, Kim IA, Park KD, Yui N, Shin JW.  Electrospun PLGA nanofiber scaffolds for articular cartilage reconstruction: mechanical stability, degradation and cellular responses under mechanical stimulation in vitro. J Biomater Sci Polym Ed. 2006, 17(1-2):103-19. *Cited over 155 times

Lee CH, Shin HJ, Cho IH, Kang YM, Kim IA, Shin JW, Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast, Biomaterials, 2005, 26(11):1261-70. *Cited over 470 times

Kim SJ, Shin JW, Lee CH, Shin HJ, Kim SH, Jeong JH, Lee JW, Biomechanical Comparisons of Three Different Tibia Tunnel Directions in Posterior Cruciate Ligament Reconstruction, Arthroscopy, 2005, 21(3): 286-293.

Park C, Kim YJ, Lee CS, An K, Shin HJ, Lee CH, Kim CH, Shin JW, An in vitro animal study of the biomechanical responses of annulus fibrosus with aging, Spine. 2005, 30(10): E259-65.