Yiping W. Han, PhD

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Overview

I am a tenured professor of microbial sciences with an interdisciplinary appointment at Columbia University Medical Center and the Vagelos College of Physicians & Surgeons.

Academic Appointments

  • Professor of Microbial Sciences (in Dental Medicine and Microbiology and Immunology, Obstetrics and Gynecology and Medical Sciences in Medicine)

Research

My research has been consistently funded by the NIH and involves the role of microbes in human health and disease. My research interests include host-pathogen interactions, human microbiome and oral-systemic connections. The human microbiome is a vast population of microbes that play an essential role in health and disease. Work in our laboratory is focused on the following aspects: (i) investigating the role of oral bacteria in extra-oral infection and inflammation; (ii) investigating the mechanisms of Fusobacterium nucleatum pathogenesis in pregnancy complications and gastrointestinal cancers; and (iii) developing genetic tools for mutant construction in bacteria.

Research Interests

  • Host-pathogen interactions
  • Human microbiome
  • Oral-systemic connections

Grants

THE ROLE OF THE MICRO ENVIRONMENT IN BARRETT S ESOPHAGUS (Federal Gov)

May 12 2017 - Apr 30 2022

FUSOBACTERIUM NUCLEATUM-MEDIATED STIMULATION OF COLORECTAL CANCER: MECHANISTIC STUDIES (Federal Gov)

Dec 1 2014 - Nov 30 2020

EFFICACY OF PHAGE COCKTAIL FOR PROTECTION AGAINST LISTERIA INFECTION IN PREGNANT MICE (Private)

Apr 19 2019 - Apr 18 2020

FUSOBACTERIUM NUCLEATUM-MEDIATED STIMULATION OF COLORECTAL CANCER: MECHANISTIC STUDIES (Federal Gov)

Dec 1 2014 - Nov 30 2019

MECHANISM OF F. NUCLEATUM IN INTRAUTERINE INFECTION (Federal Gov)

Jul 5 2014 - Jun 30 2018

MECHANISM OF F. NUCLEATUM IN INTRAUTERINE INFECTION (Federal Gov)

Jul 5 2014 - Jun 30 2017

MECHANISM OF F. NUCLEATUM IN INTRAUTERINE INFECTION (Federal Gov)

Jul 5 2014 - Jun 30 2017

INVESTIGATION OF FADA ADHESIN FROM FUSOBACTERIUM NUCLEATUM (Federal Gov)

Jul 2 2014 - Apr 30 2016

Selected Publications

Rubinstein, M.R., Baik, J.E., Lagana, S.M., Han, R.P., Raab, W.J., Sahoo, D., Dalerba, P., Wang, T.C. and Han, Y.W. (2019) Fusobacterium nucleatum promotes colorectal cancer through induction of novel Wnt/b-catenin modulator Annexin A1 in proliferating cancerous cells. EMBO Reports doi.org/10.15252/embo.201847638.1. PMID:30833345

Garcia-So, J., Zhang, X., Yang, X., Rubinstein, M.R., Mao, D.Y., Kitajewski, J, Liu, K. and Han, Y.W. (2019) Omega-3 fatty acids suppress Fusobacterium nucleatum-induced placental inflammation originating from maternal endothelial cells. JCI Insight 4: e125436. doi.org/10.1172/jci.insight.125436. PMID: 30728337

Vander Haar, E.L., So, J., Gyamfi-Bannerman, C. and Han, Y.W. (2018) Fusobacterium nucleatum and adverse pregnancy outcomes: Epidemiological and mechanistic evidence. Anaerobe 50: 55-59. PMID: 29409815